The series follows babes a trio of plump siblings who had other things on their mind besides their weight: like work, relationships, popularity, and starting a family. The ladies also shared a small one-bedroom apartment in New York City, which added to the comic friction. The Gilbert sisters include Darlene (Susan Peretz), the eldest, who was a dog groomer and recently divorced (her husband had an affair with their weight-loss counselor); Charlene (Wendie Jo Sperber), the middle sister, who was a makeup artist for a commercial photographer and was the most active one out of the three; and Marlene (Lesley Boone), the youngest sister, a former toll collector (and later an actress in a pantyhose commercial and a soap opera), who was seen as a dreamer with a naive, yet trusting, personality. Also in the cast was Charlene's boyfriend, Ronnie Underwood (Rick Overton), a restaurant owner. He disappeared at mid-season, as a result putting all three sisters on the dating market.
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